CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza.

Swain, Susan L and Agrewala, J N and Brown, Deborah M and Jelley-Gibbs, Dawn M and Golech, Susanne and Huston, Gail and Jones, Stephen C and Kamperschroer, Cris and Lee, Won-Ha and McKinstry, K Kai and Román, Eulogia and Strutt, Tara and Weng, Nan-ping (2006) CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunological reviews, 211. pp. 8-22. ISSN 0105-2896

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Abstract

We have outlined the carefully orchestrated process of CD4+ T-cell differentiation from naïve to effector and from effector to memory cells with a focus on how these processes can be studied in vivo in responses to pathogen infection. We emphasize that the regulatory factors that determine the quality and quantity of the effector and memory cells generated include (i) the antigen dose during the initial T-cell interaction with antigen-presenting cells; (ii) the dose and duration of repeated interactions; and (iii) the milieu of inflammatory and growth cytokines that responding CD4+ T cells encounter. We suggest that heterogeneity in these regulatory factors leads to the generation of a spectrum of effectors with different functional attributes. Furthermore, we suggest that it is the presence of effectors at different stages along a pathway of progressive linear differentiation that leads to a related spectrum of memory cells. Our studies particularly highlight the multifaceted roles of CD4+ effector and memory T cells in protective responses to influenza infection and support the concept that efficient priming of CD4+ T cells that react to shared influenza proteins could contribute greatly to vaccine strategies for influenza.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Springer Science.
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	17 Feb 2012 16:45
Last Modified:	07 Jan 2015 05:20
URI:	http://crdd.osdd.net/open/id/eprint/1017

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