Bachhawat, N and Singh, Balvinder (2007) Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds. Genomics, proteomics & bioinformatics / Beijing Genomics Institute, 5 (3-4). pp. 236-41. ISSN 1672-0229
Full text not available from this repository. (Request a copy)Abstract
The PE_PGRS family of proteins unique to mycobacteria is demonstrated to contain multiple calcium-binding and glycine-rich sequence motifs GGXGXD/NXUX. This sequence repeat constitutes a calcium-binding parallel beta-roll or parallel beta-helix structure and is found in RTX toxins secreted by many Gram-negative bacteria. It is predicted that the highly homologous PE PGRS proteins containing multiple copies of the nona-peptide motif could fold into similar calcium-binding structures. The implication of the predicted calcium-binding property of PE PGRS proteins in the light of macrophage-pathogen interaction and pathogenesis is presented.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Science Press. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 17 Feb 2012 16:40 |
| Last Modified: | 07 Jan 2015 09:55 |
| URI: | http://crdd.osdd.net/open/id/eprint/1036 |
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