Mir, Manzoor A and Agrewala, J N (2007) Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells. Current Immunology Reviews, 3 (3). pp. 160-169. ISSN 1875-631X
Full text not available from this repository. (Request a copy)Abstract
The role of CD80 and CD86 costimulatory molecules is well established in the activation of T cells but not antigen presenting cells. Recently, many reports in literature have demonstrated categorically the influence of CD80 and CD86 in the activation of B cells and dendritic cells. Stimulation via CD80/CD86 in B cells can modulate their proliferation, IgG secretion and expression of pro-apoptotic and anti-apoptotic molecules, nuclear localization of NF-κB p50 subunit, phosphorylation of Rel A (p65) and IκB-alpha and increased oct-2 expression. In case of dendritic cells, it has been shown that signals induced via CD80 and CD86 enhance the production of IL-6 and IFN-γ which in turn, upregulates the expression of the enzyme indolamine 2, 3-dioxygenase that results in tryptophan catabolism and affects T cell proliferation. Interestingly, it has been shown that co-stimulation through CD80 can restrict the survival of lymphomas and can also induce apoptosis in neural stem cells. Consequently, it may be concluded that CD28/CD152-CD80/86 interaction delivers a bi-directional co-stimulation, thereby not only having impact on the function of T cells, but also antigen presenting cells
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Bentham Science. |
| Uncontrolled Keywords: | Co-stimulation, bi-directional signaling, B cells, dendritic cells, CD80, CD86, CD40 |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 17 Feb 2012 16:40 |
| Last Modified: | 09 Jan 2015 08:40 |
| URI: | http://crdd.osdd.net/open/id/eprint/1042 |
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