A reappraisal of the plasmid stability problem in chemostat cultures

Patnaik, P R (2007) A reappraisal of the plasmid stability problem in chemostat cultures. Indian Journal of Biotechnology, 6. pp. 267-270. ISSN 0975-0967 (Online); 0972-5849 (Print)

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Segregational instability models of recombinant bacteria conventionally assume that ¾(a) the probability of loss of a unit of a plasmid is constant and (b) upon cell division, the progeny either inherit the mother’s plasmid content entirely or not at all. However, two previous studies have shown that neither assumption is correct. So, in this work, both assumptions have been relaxed to formulate a more general model of plasmid dynamics in a chemostat. Unlike earlier work, this model predicts a time-dependent dilution rate to maximize segregational stability. Some biological implications are discussed.

Item Type: Article
Additional Information: OPEN ACCESS
Uncontrolled Keywords: chemostat, decay probability variation, Escherichia coli, plasmid stability
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 17 Feb 2012 16:39
Last Modified: 17 Feb 2012 16:39
URI: http://crdd.osdd.net/open/id/eprint/1052

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