Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii

Srinivasan, V. B. and Rajamohan, Govindan and Gebreyes, Wondwossen A (2009) Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 53 (12). pp. 5312-5316. ISSN 0066-4804

PDF rajamohan2009.pdf - Published Version Restricted to Registered users only Download (659Kb) | Request a copy

Abstract

In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in decreased susceptibility to various classes of antimicrobial agents, detergents, and dyes. Deletion of the abeS gene in A. baumannii confirmed its role in conferring resistance to these compounds.

Item Type:	Article
Additional Information:	Copyright of this article belongs to ASM.
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	28 Feb 2012 16:12
Last Modified:	07 Jan 2015 06:44
URI:	http://crdd.osdd.net/open/id/eprint/1082

Actions (login required)

View Item