Kalia, S.B. and Kaushal, G. and Kumar(1), Manoj and Cameotra, Swaranjit Singh and Sharma, A. and Verma , M.L. and Kanwar, S.S. (2009) Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands. Brazilian Journal of Microbiology, 40. pp. 916-922. ISSN 1517-8382
|
PDF
swaranjit2009.pdf - Published Version Download (123Kb) | Preview |
Abstract
A few mixed ligand transition metal carbodithioate complexes of the general formula [M(4- MPipzcdt)x(phen)y]Y (M = Mn(II), Co(II), Zn(II); 4-MPipzcdt = 4-methylpiperazine-1-carbodithioate; phen = 1,10-phenanthroline; x = 1 and y = 2 when Y = Cl; x = 2 and y = 1 when Y = nil) were synthesized and screened for their antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis by disk diffusion method. All the complexes exhibited prominent antimicrobial activity against tested pathogenic strains with the MIC values in the range <8-512 �gmL-1. The complexes [Mn(4-MPipzcdt)2(phen)] and [Co(4- MPipzcdt)(phen)2]Cl inhibited the growth of Candida albicans at a concentration as low as 8 μgmL-1. The complexes were also evaluated for their toxicity towards human transformed rhabdomyosarcoma cells (RD cells). Moderate cell viability of the RD cells was exhibited against the metal complexes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antimicrobial, metal ions, 4-methylpiperazine-1-carbodithioate, MIC, zone of inhibition |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 28 Feb 2012 16:11 |
| Last Modified: | 01 Mar 2016 06:28 |
| URI: | http://crdd.osdd.net/open/id/eprint/1089 |
Actions (login required)
 |
View Item |
