The mechanism of redox sensing in Mycobacterium tuberculosis.

Bhat, Shabir Ahmed and Singh, Nisha and Trivedi, Abhishek and Kansal, Pallavi and Gupta, Pawan and Kumar, Ashwani (2012) The mechanism of redox sensing in Mycobacterium tuberculosis. Free radical biology & medicine, 53 (8). pp. 1625-41. ISSN 1873-4596

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Abstract

Tuberculosis epidemics have defied constraint despite the availability of effective treatment for the past half-century. Mycobacterium tuberculosis, the causative agent of TB, is continually exposed to a number of redox stressors during its pathogenic cycle. The mechanisms used by Mtb to sense redox stress and to maintain redox homeostasis are central to the success of Mtb as a pathogen. Careful analysis of the Mtb genome has revealed that Mtb lacks classical redox sensors such as FNR, FixL, and OxyR. Recent studies, however, have established that Mtb is equipped with various sophisticated redox sensors that can detect diverse types of redox stress, including hypoxia, nitric oxide, carbon monoxide, and the intracellular redox environment. Some of these sensors, such as heme-based DosS and DosT, are unique to mycobacteria, whereas others, such as the WhiB proteins and anti-σ factor RsrA, are unique to actinobacteria. This article provides a comprehensive review of the literature on these redox-sensory modules in the context of TB pathogenesis.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Elsevier Science.
Uncontrolled Keywords:	Redox homeostasis; Redox sensing; Virulence; DosS; DosT; DosR; WhiB3; Anti-σ factors; Serine–threonine kinases; Metabolic flexibility; Free radicals
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	31 Jan 2013 04:10
Last Modified:	07 Jan 2015 10:03
URI:	http://crdd.osdd.net/open/id/eprint/1222

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