Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.

Sheokand, Navdeep and Kumar, Santosh and Malhotra, Himanshu and Tillu, Vikas and Raje, Chaaya Iyengar and Raje, Manoj (2013) Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition. Biochimica et biophysica acta, 1830 (6). pp. 3816-27. ISSN 0006-3002

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Abstract

The long held view is that mammalian cells obtain transferrin (Tf) bound iron utilizing specialized membrane anchored receptors. Here we report that, during increased iron demand, cells secrete the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) which enhances cellular uptake of Tf and iron.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Elsevier Science.
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	24 Jun 2013 11:33
Last Modified:	18 Jul 2013 04:34
URI:	http://crdd.osdd.net/open/id/eprint/1293

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