Hybrid approach for predicting coreceptor used by HIV-1 from its V3 loop amino acid sequence.

Kumar, Ravi and Raghava, G.P.S. (2013) Hybrid approach for predicting coreceptor used by HIV-1 from its V3 loop amino acid sequence. PloS one, 8 (4). e61437. ISSN 1932-6203

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Abstract

HIV-1 infects the host cell by interacting with the primary receptor CD4 and a coreceptor CCR5 or CXCR4. Maraviroc, a CCR5 antagonist binds to CCR5 receptor. Thus, it is important to identify the coreceptor used by the HIV strains dominating in the patient. In past, a number of experimental assays and in-silico techniques have been developed for predicting the coreceptor tropism. The prediction accuracy of these methods is excellent when predicting CCR5(R5) tropic sequences but is relatively poor for CXCR4(X4) tropic sequences. Therefore, any new method for accurate determination of coreceptor usage would be of paramount importance to the successful management of HIV-infected individuals.

Item Type:	Article
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	24 Jun 2013 10:57
Last Modified:	24 Jun 2013 10:57
URI:	http://crdd.osdd.net/open/id/eprint/1305

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