Tuteja, Satish K and Priyanka, and Bhalla, Vijayender and Deep, Akash and Paul, A K and Suri, C Raman (2014) Graphene-gated biochip for the detection of cardiac marker Troponin I. Analytica chimica acta, 809. pp. 148-54. ISSN 1873-4324
Full text not available from this repository. (Request a copy)Abstract
We report lithium ion intercalation mediated efficient exfoliation of graphite to form monolithic graphene sheets which have subsequently been investigated for the development of highly sensitive label-free electrochemical detection platform for cardiac biomarker, Troponin I (cTnI). The spectroscopic and morphological analysis demonstrated the formation of defect free graphene sheets which were successfully employed to fabricate an inter-digited microdevice in a drain-source configuration on a silicon biochip. The graphene gated biochip functionalized with anti-cTnI antibodies used in label free detection of cTnI which exhibited an excellent sensitivity in the picogram range (~1 pg mL(-1)) for cTnI without the use of any enzymatic amplification that promises its potential applicability for bio-molecular detection in clinical diagnosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Biochip; Graphene sheets; Lithium ion intercalation; Troponin I |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 09 Feb 2015 05:49 |
| Last Modified: | 09 Feb 2015 05:49 |
| URI: | http://crdd.osdd.net/open/id/eprint/1545 |
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