Caerulomycin A suppresses immunity by inhibiting T cell activity.

Singla, Arvind K and Gurram, Rama Krishna and Chauhan, Arun and Khatri, Neeraj and Vohra, Rakesh M and Jolly, R S and Agrewala, J N (2014) Caerulomycin A suppresses immunity by inhibiting T cell activity. PloS one, 9 (10). e107051. ISSN 1932-6203

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Official URL: http://journals.plos.org/plosone/article?id=10.137...

Abstract

Caerulomycin A (CaeA) is a known antifungal and antibiotic agent. Further, CaeA is reported to induce the expansion of regulatory T cell and prolongs the survival of skin allografts in mouse model of transplantation. In the current study, CaeA was purified and characterized from a novel species of actinomycetes, Actinoalloteichus spitiensis. The CaeA was identified for its novel immunosuppressive property by inhibiting in vitro and in vivo function of T cells.

Item Type: Article
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 09 Feb 2015 10:59
Last Modified: 22 Jul 2015 04:28
URI: http://crdd.osdd.net/open/id/eprint/1564

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