Sharma, Arun and Singla, Deepak and Rashid, Mamoon and Raghava, G.P.S. (2014) Designing of peptides with desired half-life in intestine-like environment. BMC bioinformatics, 15. p. 282. ISSN 1471-2105
Full text not available from this repository. (Request a copy)Abstract
In past, a number of peptides have been reported to possess highly diverse properties ranging from cell penetrating, tumor homing, anticancer, anti-hypertensive, antiviral to antimicrobials. Owing to their excellent specificity, low-toxicity, rich chemical diversity and availability from natural sources, FDA has successfully approved a number of peptide-based drugs and several are in various stages of drug development. Though peptides are proven good drug candidates, their usage is still hindered mainly because of their high susceptibility towards proteases degradation. We have developed an in silico method to predict the half-life of peptides in intestine-like environment and to design better peptides having optimized physicochemical properties and half-life.
| Item Type: | Article |
|---|---|
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 10 Feb 2015 06:09 |
| Last Modified: | 20 Jul 2015 06:08 |
| URI: | http://crdd.osdd.net/open/id/eprint/1586 |
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