Perspectives in the modeling and optimization of PHB production by pure and mixed cultures.

Patnaik, Pratap R (2005) Perspectives in the modeling and optimization of PHB production by pure and mixed cultures. Critical reviews in biotechnology, 25 (3). pp. 153-71. ISSN 0738-8551

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Abstract

Poly(beta-hydroxybutyrate) or PHB is an important member of the family of polyhydroxyalkanoates with properties that make it potentially competitive with synthetic polymers. In addition, PHB is biodegradable. While the biochemistry of PHB synthesis by microorganisms is well known, improvement of large-scale productivity requires good fermentation modeling and optimization. The latter aspect is reviewed here. Current models are of two types: (i) mechanistic and (ii) cybernetic. The models may be unstructured or structured, and they have been applied to single cultures and co-cultures. However, neither class of models expresses adequately all the important features of large-scale non-ideal fermentations. Model-independent neural networks provide faithful representations of observations, but they can be difficult to design. So hybrid models, combining mechanistic, cybernetic and neural models, offer a useful compromise. All three kinds of basic models are discussed with applications and directions toward hybrid model development.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Informa Healthcare.
Uncontrolled Keywords:	Perspectives in the modeling and optimization of PHB production by pure and mixed cultures
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	09 Jan 2012 04:25
Last Modified:	10 Jan 2012 15:30
URI:	http://crdd.osdd.net/open/id/eprint/161

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