Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1, p62 and NBR1) in human bladder cancer cells.

Ishaq, Mohammad and Khan, Mohammad Aslam and Sharma, Kapil and Sharma, Gaurav and Dutta, Rajesh Kumar and Majumdar, Sekhar (2014) Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1, p62 and NBR1) in human bladder cancer cells. Biochimica et biophysica acta, 1840 (12). pp. 3374-84. ISSN 0006-3002

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Abstract

Gambogic acid is a potent anticancer agent and has been found effective against various types of cancer cells. The present study was addressed to explore the cytotoxic potential of Gambogic acid and the modulation of autophagy and apoptosis in bladder cancer cells T24 and UMUC3.

Item Type: Article
Additional Information: Copyright of this article belongs to Elsevier.
Uncontrolled Keywords: Gambogic acid; Bladder cancer; Apoptosis; Autophagy; p62
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 20 Jul 2015 05:32
Last Modified: 20 Jul 2015 05:32
URI: http://crdd.osdd.net/open/id/eprint/1676

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