Singh, Jagmohan (2014) Role of DNA replication in establishment and propagation of epigenetic states of chromatin. Seminars in cell & developmental biology, 30. pp. 131-43. ISSN 1096-3634
Full text not available from this repository. (Request a copy)Abstract
DNA replication is the fundamental process of duplication of the genetic information that is vital for survival of all living cells. The basic mechanistic steps of replication initiation, elongation and termination are conserved among bacteria, lower eukaryotes, like yeast and metazoans. However, the details of the mechanisms are different. Furthermore, there is a close coordination between chromatin assembly pathways and various components of replication machinery whereby DNA replication is coupled to "chromatin replication" during cell cycle. Thereby, various epigenetic modifications associated with different states of gene expression in differentiated cells and the related chromatin structures are faithfully propagated during the cell division through tight coupling with the DNA replication machinery. Several examples are found in lower eukaryotes like budding yeast and fission yeast with close parallels in metazoans.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Elsevier Science. |
| Uncontrolled Keywords: | DNA replication; Chromatin; Epigenetic states; Chromatin assembly and remodeling factors |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 20 Jul 2015 04:32 |
| Last Modified: | 20 Jul 2015 04:32 |
| URI: | http://crdd.osdd.net/open/id/eprint/1693 |
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