Yadav, Inderjit S and Singh, Harinder and Khan, Mohd Imran and Chaudhury, Ashok and Raghava, G.P.S. and Agarwal, Subhash M (2014) EGFRIndb: epidermal growth factor receptor inhibitor database. Anti-cancer agents in medicinal chemistry, 14 (7). pp. 928-35. ISSN 1875-5992
Full text not available from this repository. (Request a copy)Abstract
Aberrant activity of epidermal growth factor receptor (EGFR) family proteins has been found to be associated with a number of human cancers including that of lung and breast. Consequently, the search for EGFR family inhibitors, a well established target of pharmacological and therapeutic value has been ongoing. Therefore, over the years several small molecules, which compete for ATP in the kinase domain have been synthesised and some of them have proved to be effective in attenuating EGFR mediated proliferation. Thus, there exists in literature a vast amount of experimental data on EGFR tyrosine kinase inhibitors. In this paper, we describe a comprehensive database EGFRIndb that contains details of the small molecular inhibitors of EGFR family.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Bentham science. |
| Uncontrolled Keywords: | Database, Epidermal growth factor receptor, cancer, tyrosine kinase inhibitors, dual inhibitors, irreversible inhibitors - See more at: http://www.eurekaselect.com/121100/article#sthash.X43gYlM9.dpuf |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 20 Jul 2015 03:27 |
| Last Modified: | 20 Jul 2015 06:10 |
| URI: | http://crdd.osdd.net/open/id/eprint/1716 |
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