Kaur, Gurmeet and Subramanian, Srikrishna (2015) A novel RING finger in the C-terminal domain of the coatomer protein α-COP. Biology direct, 10 (1). p. 70. ISSN 1745-6150
Full text not available from this repository. (Request a copy)Abstract
The C-terminal domain of α-COP, an essential subunit of the COPI coatomer complex, is composed of an all α-helical region and a small β-sheet domain. We show that this β-sheet domain is a Really Interesting New Gene (RING)-like treble clef zinc finger. The zinc-binding residues are substituted by other aminoacids in many homologs including the structurally-characterized proteins from Saccharomyces cerevisiae and Bos taurus. This RING-like domain is possibly related to those of other vesicle membrane-associated complexes, such as CORVET, HOPS and SEA, and likely mediates interactions with Dsl1p and assist in coat oligomerization.
| Item Type: | Article |
|---|---|
| Additional Information: | Open Access |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 29 Jan 2016 07:07 |
| Last Modified: | 29 Jan 2016 07:07 |
| URI: | http://crdd.osdd.net/open/id/eprint/1734 |
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