Sonkusre, Praveen and Singh Cameotra, Swaranjit (2015) Biogenic selenium nanoparticles inhibit Staphylococcus aureus adherence on different surfaces. Colloids and surfaces. B, Biointerfaces, 136. pp. 1051-7. ISSN 1873-4367
Full text not available from this repository. (Request a copy)Abstract
The global issue of nosocomial infection is owing to bacterial colonization and biofilm formation on medical devices which primarily affects critically ill and/or immuno-compromised patients and also leads to malfunctioning of the devices. Therefore, it is desirable to prevent bacterial colonization on these devices by coating with a non toxic antimicrobial agent or bacterial adherence inhibitor. Here we have shown Bacillus licheniformis JS2 derived selenium nanoparticles (SeNPs) inhibit Staphylococcus aureus adherence and micro-colony formation on polystyrene, glass, and catheter surface. Results indicated that, the coating of these non toxic biogenic SeNPs, at a concentration of 0.5mgSe/ml, prohibits bacterial load to more than 60% on glass and catheter surface, when incubated at 4°C for 24h in phosphate buffered saline. Furthermore, confocal and electron microscopic observations strongly suggested the inhibition of biofilm and micro-colony formation on SeNP coated glass and catheter surfaces when cultured at 37°C for 72h in a nutrient rich medium. The study suggests that coating of biogenic SeNPs on medical devices could be an alternative approach for prevention of biofilm related infections.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Elsevier Science. |
| Uncontrolled Keywords: | Adherence; Bacillus licheniformis JS2; Biofilm formation; Micro-colony; Selenium nanoparticles; Staphylococcus aureus |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 29 Jan 2016 06:54 |
| Last Modified: | 29 Jan 2016 06:54 |
| URI: | http://crdd.osdd.net/open/id/eprint/1738 |
Actions (login required)
 |
View Item |
