SATPdb: a database of structurally annotated therapeutic peptides.

Singh, Sandeep and Chaudhary, Kumardeep and Dhanda, Sandeep Kumar and Bhalla, Sherry and Usmani, Salman Sadullah and Gautam, Ankur and Tuknait, Abhishek and Agrawal, Piyush and Mathur, Deepika and Raghava, G.P.S. (2016) SATPdb: a database of structurally annotated therapeutic peptides. Nucleic acids research, 44 (D1). D1119-26. ISSN 1362-4962

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Abstract

SATPdb (http://crdd.osdd.net/raghava/satpdb/) is a database of structurally annotated therapeutic peptides, curated from 22 public domain peptide databases/datasets including 9 of our own. The current version holds 19192 unique experimentally validated therapeutic peptide sequences having length between 2 and 50 amino acids. It covers peptides having natural, non-natural and modified residues. These peptides were systematically grouped into 10 categories based on their major function or therapeutic property like 1099 anticancer, 10585 antimicrobial, 1642 drug delivery and 1698 antihypertensive peptides. We assigned or annotated structure of these therapeutic peptides using structural databases (Protein Data Bank) and state-of-the-art structure prediction methods like I-TASSER, HHsearch and PEPstrMOD. In addition, SATPdb facilitates users in performing various tasks that include: (i) structure and sequence similarity search, (ii) peptide browsing based on their function and properties, (iii) identification of moonlighting peptides and (iv) searching of peptides having desired structure and therapeutic activities. We hope this database will be useful for researchers working in the field of peptide-based therapeutics.

Item Type:	Article
Additional Information:	Open Access
Uncontrolled Keywords:	Therapeutic peptides
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	29 Jan 2016 06:45
Last Modified:	29 Sep 2016 06:14
URI:	http://crdd.osdd.net/open/id/eprint/1742

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