Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines.

Singh, Harinder and Gupta, Sudheer and Gautam, Ankur and Raghava, G.P.S. (2015) Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines. Methods in molecular biology (Clifton, N.J.), 1348. pp. 327-40. ISSN 1940-6029

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Rationally designed subunit vaccines mainly consist of small peptides or B-cell epitopes, which can stimulate the body's immune response. Development of subunit vaccines is a very tedious and costly process. One of the imperative and crucial steps of vaccine development is the identification of highly competent B-cell epitopes as most of the proteins and fragments of proteins are immunologically irrelevant. With the advances in bioinformatics tools, it can be possible to precisely narrow down potential B-cell epitopes from the whole proteome of any pathogen. This chapter sheds light on prediction and designing of B-cell epitopes using two in silico tools LBtope and IgPred.

Item Type: Article
Additional Information: Copyright of this article belongs to Springer.
Uncontrolled Keywords: B-cell epitopes; Bioinformatics; IgPred; In silico; LBtope; Vaccine
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 29 Jan 2016 04:42
Last Modified: 29 Jan 2016 04:42

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