Khan, Nargis and Vidyarthi, Aurobind and Pahari, Susanta and Negi, Shikha and Aqdas, Mohammad and Nadeem, Sajid and Agnihotri, Tapan and Agrewala, J N (2016) Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy. Scientific reports, 6. p. 19084. ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
T cells play a cardinal role in mediating protection against intracellular pathogens like Mycobacterium tuberculosis (Mtb). It is important to understand the factors that govern the T cell response; thereby can modulate its activity. Dendritic cells (DCs) are the major player in initiation and augmentation of T cell response. Targeting DCs to induce their optimum maturation and activation can lead to a better T cell response. Interestingly, we observed that combinatorial signaling of DCs through NOD-2 and TLR-4 fortified better yield of IL-12p40/70, IL-6 and IFN-γ and upregulated the expression of CD40, CD80 and CD86 costimulatory molecules. Further, we noticed improved phagocytic capabilities of DCs. Furthermore, NOD-2 and TLR-4 induced autophagy in DCs, which enhanced the activation of T cells. This study signifies that NOD-2 and TLR-4 exhibit synergism in invigorating the activity of DCs. Consequently, this strategy may have significant immunotherapeutic potential in bolstering the function of DCs and thus improving the immunity against pathogens.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to NPG. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 01 Feb 2016 13:00 |
| Last Modified: | 01 Feb 2016 13:00 |
| URI: | http://crdd.osdd.net/open/id/eprint/1812 |
Actions (login required)
 |
View Item |
