Kujur, Weshely and Gurram, Rama Krishna and Haleem, Nazia and Maurya, Sudeep K and Agrewala, J N (2015) Caerulomycin A inhibits Th2 cell activity: a possible role in the management of asthma. Scientific reports, 5. p. 15396. ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
We have recently demonstrated that Caerulomycin A induces regulatory T cells differentiation by suppressing Th1 cells activity. The role of regulatory T cells is well established in suppressing the function of Th2 cells. Th2 cells are known to inflict the induction of the activation of asthma. Consequently, in the present study, we monitored the influence of Caerulomycin A in inhibiting the activity of Th2 cells and its impact in recuperating asthma symptoms. Interestingly, we observed that Caerulomycin A significantly suppressed the differentiation of Th2 cells, as evidenced by downregulation in the GATA-3 expression. Further, decline in the levels of IL-4, IL-5 and IL-13 cytokines and IgE was noted in the animals suffering from asthma. Furthermore, we noticed substantial suppression in the inflammatory response and number of eosinophils in the lungs. In essence, this study signifies an important therapeutic role of Caerulomycin A in asthma.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to NPG. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 01 Feb 2016 13:04 |
| Last Modified: | 01 Feb 2016 13:04 |
| URI: | http://crdd.osdd.net/open/id/eprint/1813 |
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