Transcription factors and cognate signalling cascades in the regulation of autophagy.

Chandra, Vemika and Bhagyaraj, Ella and Parkesh, Raman and Gupta, Pawan (2016) Transcription factors and cognate signalling cascades in the regulation of autophagy. Biological reviews of the Cambridge Philosophical Society, 91 (2). pp. 429-51. ISSN 1469-185X

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Autophagy is a process that maintains the equilibrium between biosynthesis and the recycling of cellular constituents; it is critical for avoiding the pathophysiology that results from imbalance in cellular homeostasis. Recent reports indicate the need for the design of high-throughput screening assays to identify targets and small molecules for autophagy modulation. For such screening, however, a better understanding of the regulation of autophagy is essential. In addition to regulation by various signalling cascades, regulation of gene expression by transcription factors is also critical. This review focuses on the various transcription factors as well as the corresponding signalling molecules that act together to translate the stimuli to effector molecules that up- or downregulate autophagy. This review rationalizes the importance of these transcription factors functioning in tandem with cognate signalling molecules and their interfaces as possible therapeutic targets for more specific pharmacological interventions.

Item Type: Article
Additional Information: Copyright of this article belongs to Wiley.
Uncontrolled Keywords: autophagy; gene regulation; nuclear receptors; signalling molecules; transcription factors
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 30 Sep 2016 04:56
Last Modified: 30 Sep 2016 04:56

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