ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.

Gupta, Amit Kumar and Kaur, Karambir and Rajput, Akanksha and Dhanda, Sandeep Kumar and Sehgal, Manika and Khan, Md Shoaib and Monga, Isha and Dar, Showkat Ahmad and Singh, Sandeep and Nagpal, Gandharva and Usmani, Salman Sadullah and Thakur, Anamika and Kaur, Gazaldeep and Sharma, Shivangi and Bhardwaj, Aman and Qureshi, Abid and Raghava, G.P.S. and Kumar, Manoj (2016) ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis. Scientific reports, 6. p. 32713. ISSN 2045-2322

[img] PDF (Open Access)
28.pdf - Published Version

Download (2214Kb)
Official URL: http://www.nature.com/articles/srep32713


Current Zika virus (ZIKV) outbreaks that spread in several areas of Africa, Southeast Asia, and in pacific islands is declared as a global health emergency by World Health Organization (WHO). It causes Zika fever and illness ranging from severe autoimmune to neurological complications in humans. To facilitate research on this virus, we have developed an integrative multi-omics platform; ZikaVR (http://bioinfo.imtech.res.in/manojk/zikavr/), dedicated to the ZIKV genomic, proteomic and therapeutic knowledge. It comprises of whole genome sequences, their respective functional information regarding proteins, genes, and structural content. Additionally, it also delivers sophisticated analysis such as whole-genome alignments, conservation and variation, CpG islands, codon context, usage bias and phylogenetic inferences at whole genome and proteome level with user-friendly visual environment. Further, glycosylation sites and molecular diagnostic primers were also analyzed. Most importantly, we also proposed potential therapeutically imperative constituents namely vaccine epitopes, siRNAs, miRNAs, sgRNAs and repurposing drug candidates.

Item Type: Article
Additional Information: Open Access
Uncontrolled Keywords: Computational platforms and environments;Genetic databases;Genome informaticsVirology
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 29 Sep 2016 10:36
Last Modified: 29 Sep 2016 10:36
URI: http://crdd.osdd.net/open/id/eprint/1869

Actions (login required)

View Item View Item