Gautam, Vikas and Patil, Prashant P. and Kumar, Sunil and Midha, Samriti and Kaur, Mandeep and Kaur, Satinder and Singh, Meenu and Mali, Swapna and Shastri, Jayanthi and Arora, Anita and Ray, Pallab and Patil, Prabhu B. (2016) Multilocus sequence analysis reveals high genetic diversity in clinical isolates of Burkholderia cepacia complex from India. Scientific Reports, 6 (1). ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
Burkholderia cepacia complex (Bcc) is a complex group of bacteria causing opportunistic infections in immunocompromised and cystic fibrosis (CF) patients. Herein, we report multilocus sequence typing and analysis of the 57 clinical isolates of Bcc collected over the period of seven years (2005-2012) from several hospitals across India. A total of 21 sequence types (ST) including two STs from cystic fibrosis patient's isolates and twelve novel STs were identified in the population reflecting the extent of genetic diversity. Multilocus sequence analysis revealed two lineages in population, a major lineage belonging to B. cenocepacia and a minor lineage belonging to B. cepacia. Split-decomposition analysis suggests absence of interspecies recombination and intraspecies recombination contributed in generating genotypic diversity amongst isolates. Further linkage disequilibrium analysis indicates that recombination takes place at a low frequency, which is not sufficient to break down the clonal relationship. This knowledge of the genetic structure of Bcc population from a rapidly developing country will be invaluable in the epidemiology, surveillance and understanding global diversity of this group of a pathogen.
| Item Type: | Article |
|---|---|
| Additional Information: | Open Access |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 26 Mar 2018 10:22 |
| Last Modified: | 26 Mar 2018 10:22 |
| URI: | http://crdd.osdd.net/open/id/eprint/1956 |
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