In Silico Tools and Databases for Designing Peptide-Based Vaccine and Drugs.

Usmani, Salman Sadullah and Kumar, Rajesh and Bhalla, Sherry and Kumar, Vinod and Raghava, G.P.S. (2018) In Silico Tools and Databases for Designing Peptide-Based Vaccine and Drugs. Advances in protein chemistry and structural biology, 112. pp. 221-263. ISSN 1876-1631

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The prolonged conventional approaches of drug screening and vaccine designing prerequisite patience, vigorous effort, outrageous cost as well as additional manpower. Screening and experimentally validating thousands of molecules for a specific therapeutic property never proved to be an easy task. Similarly, traditional way of vaccination includes administration of either whole or attenuated pathogen, which raises toxicity and safety issues. Emergence of sequencing and recombinant DNA technology led to the epitope-based advanced vaccination concept, i.e., small peptides (epitope) can stimulate specific immune response. Advent of bioinformatics proved to be an adjunct in vaccine and drug designing. Genomic study of pathogens aid to identify and analyze the protective epitope. A number of in silico tools have been developed to design immunotherapy as well as peptide-based drugs in the last two decades. These tools proved to be a catalyst in drug and vaccine designing. This review solicits therapeutic peptide databases as well as in silico tools developed for designing peptide-based vaccine and drugs.

Item Type: Article
Additional Information: Copyright of this article belongs to Elsevier.
Uncontrolled Keywords: Drug designing; Immunotherapeutic; Peptide databases; Peptide therapeutics; Vaccine
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 09 Aug 2018 06:19
Last Modified: 09 Aug 2018 06:19

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