Showkat, Ahmad and Kumar, Manoj (2018) saRNAdb: Resource of Small Activating RNAs for Up-regulating the Gene Expression. Journal of molecular biology, 430 (15). pp. 2212-2218. ISSN 1089-8638
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RNA activation (RNAa) is the process of enhancing selective gene expression at transcriptional level using double-stranded RNAs, targeting gene promoter. These RNA molecules are usually 21 nucleotides long and termed as small activating RNAs (saRNAs). They are involved in gene regulation, epigenetics, gain-of-function studies and have potential therapeutic applications for various diseases especially cancer. RNAa is opposite to RNA interference in functionality; however, both processes share some protein machinery. There are many RNA interference centered online resources but no one for saRNAs; therefore, we developed "saRNAdb" database (http://bioinfo.imtech.res.in/manojk/sarna/). It contains 2150 manually curated saRNA entries with detailed information about their nucleotide sequences, activities, corresponding target gene, promoter and other experimental data. Besides, saRNA-promoter binding location, predicted saRNA features, tools (off-target, map) and RNAa-related proteins with their interacting partners are provided. saRNAdb is expected to assist in RNA research especially for nucleic acid-based therapeutics development.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Elsevier. |
| Uncontrolled Keywords: | RNA activation; RNA interference; RNA-induced transcriptional activation; small activating RNA; small interfering RNA |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 09 Aug 2018 06:06 |
| Last Modified: | 09 Aug 2018 06:06 |
| URI: | http://crdd.osdd.net/open/id/eprint/2103 |
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