Srinivasan, Vijaya Bharathi and Angrasan, Mahavinod and Chandel, Neha and Rajamohan, Govindan (2018) Genome sequence and comparative analysis of Bacillus cereus BC04, reveals genetic diversity and alterations for antimicrobial resistance. Functional & integrative genomics, 18 (4). pp. 477-487. ISSN 1438-7948
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In this study, we delineated the genome sequence of a Bacillus cereus strain BC04 isolated from a stool sample in India. The draft genome is 5.1 Mb in size and consists of total 109 scaffolds, GC content is 35.2% with 5182 coding genes. The comparative analysis with other completely sequenced genomes highlights the unique presence of genomic islands, hemolysin, capsular synthetic protein, modifying enzymes accC7 and catA15, regulators of antibiotic resistance MarR and LysR with annotated functions related to virulence, stress response, and antimicrobial resistance. Overall, this study not only signifies the genetic diversity in gut isolate BC04 in particular, but also pinpoints the presence of unique genes possessed by B. cereus which can be pertinently exploited to design novel drugs and intervention strategies for the treatment of food borne diseases.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Springer. |
| Uncontrolled Keywords: | Active efflux; Antimicrobial resistance; Bacillus; Human microbiome; Indian gut isolate |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 09 Aug 2018 06:00 |
| Last Modified: | 09 Aug 2018 06:00 |
| URI: | http://crdd.osdd.net/open/id/eprint/2104 |
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