Bacteriocins: perspective for the development of novel anticancer drugs.

Baindara, Piyush and Korpole, Suresh and Grover, Vishakha (2018) Bacteriocins: perspective for the development of novel anticancer drugs. Applied microbiology and biotechnology, 102 (24). pp. 10393-10408. ISSN 1432-0614

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Antimicrobial peptides (AMPs) from prokaryotic source also known as bacteriocins are ribosomally synthesized by bacteria belonging to different eubacterial taxonomic branches. Most of these AMPs are low molecular weight cationic membrane active peptides that disrupt membrane by forming pores in target cell membranes resulting in cell death. While these peptides known to exhibit broad-spectrum antimicrobial activity, including antibacterial and antifungal, they displayed minimal cytotoxicity to the host cells. Their antimicrobial efficacy has been demonstrated in vivo using diverse animal infection models. Therefore, we have discussed some of the promising peptides for their ability towards potential therapeutic applications. Further, some of these bacteriocins have also been reported to exhibit significant biological activity against various types of cancer cells in different experimental studies. In fact, differential cytotoxicity towards cancer cells as compared to normal cells by certain bacteriocins directs for a much focused research to utilize these compounds as novel therapeutic agents. In this review, bacteriocins that demonstrated antitumor activity against diverse cancer cell lines have been discussed emphasizing their biochemical features, selectivity against extra targets and molecular mechanisms of action.

Item Type: Article
Additional Information: Copyright of this article belongs to Springer Nature.
Uncontrolled Keywords: Anticancer; Antimicrobial peptides; Bacteriocin; Cationic; Cell lines; Lantibiotic
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 19 Mar 2019 11:28
Last Modified: 19 Mar 2019 11:28

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