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Full text not available from this repository. (Request a copy)Abstract
The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobacterium tuberculosis (Mtb) infection interferes in the antigen processing and presentation of BCG in inducing protective immunity against Mtb. Thereby, indicating that any vaccine that require extensive antigen processing may not be efficacious in TB-endemic zones. Recently, we have demonstrated that the vaccine candidate L91, which is composed of lipidated promiscuous MHC-II binder epitope, derived from latency associated Acr1 antigen of Mtb is immunogenic in the murine and Guinea pig models of TB and conferred better protection than BCG against Mtb.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Springer nature. |
| Uncontrolled Keywords: | Mtb; Multistage vaccine; Promiscuous peptide; TB; TLR-2; Th1 cells; Th17 cells |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 19 Mar 2019 09:48 |
| Last Modified: | 19 Mar 2019 09:48 |
| URI: | http://crdd.osdd.net/open/id/eprint/2143 |
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