Negi, Shikha and Pahari, Susanta and Das, Deepjyoti Kumar and Khan, Nargis and Agrewala, J N (2019) Curdlan Limits Survival Through STAT-1 Regulated Nitric Oxide Production. Frontiers in microbiology, 10. p. 1173. ISSN 1664-302X
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Host-directed therapies have emerged as an innovative and promising approach in tuberculosis (TB) treatment due to the observed limitations of current TB regimen such as lengthy duration and emergence of drug resistance. Thus, we explored the role of curdlan (beta glucan polysaccharide) as a novel strategy to activate macrophages against (). The aim of the study was to investigate the role of curdlan in restricting the growth both and . Further, the immunomodulatory potential of curdlan against and the underlying mechanism is largely unknown. We found that curdlan treatment enhanced the antigen presentation, pro-inflammatory cytokines, uptake and killing activity of macrophages. studies showed that curdlan therapy significantly reduced the burden in lung and spleen of mice. Administration of curdlan triggered the protective Th1 and Th17 immunity while boosting the central and effector memory response in infected mice. Curdlan mediated anti- activity is through signal transducer and activator of transcription-1 (STAT-1), which regulates nitric oxide (NO) production through inducible NO synthase (iNOS) induction; along with this activation of nuclear factor kappa B (NF-κB) was also evident in infected macrophages. Thus, we demonstrate that curdlan exerts effective anti-tuberculous activity anti-tuberculous activity. It can be used as a potential host-directed therapy against .
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Frontiers Media S.A. |
| Uncontrolled Keywords: | T cells; curdlan; host-directed therapy; iNOS; macrophages; tuberculosis |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 13 Aug 2019 14:35 |
| Last Modified: | 13 Aug 2019 14:35 |
| URI: | http://crdd.osdd.net/open/id/eprint/2346 |
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