Tyagi, Atul and Kapoor, Pallavi and Kumar, Rahul and Chaudhary, Kumardeep and Gautam, Ankur and Raghava, G.P.S. (2013) In silico models for designing and discovering novel anticancer peptides. Scientific reports, 3. p. 2984. ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
Use of therapeutic peptides in cancer therapy has been receiving considerable attention in the recent years. Present study describes the development of computational models for predicting and discovering novel anticancer peptides. Preliminary analysis revealed that Cys, Gly, Ile, Lys, and Trp are dominated at various positions in anticancer peptides. Support vector machine models were developed using amino acid composition and binary profiles as input features on main dataset that contains experimentally validated anticancer peptides and random peptides derived from SwissProt database. In addition, models were developed on alternate dataset that contains antimicrobial peptides instead of random peptides. Binary profiles-based model achieved maximum accuracy 91.44% with MCC 0.83. We have developed a webserver, which would be helpful in: (i) predicting minimum mutations required for improving anticancer potency; (ii) virtual screening of peptides for discovering novel anticancer peptides, and (iii) scanning natural proteins for identification of anticancer peptides (http://crdd.osdd.net/raghava/anticp/).
| Item Type: | Article |
|---|---|
| Additional Information: | Open Access |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 05 Sep 2019 11:53 |
| Last Modified: | 05 Sep 2019 11:53 |
| URI: | http://crdd.osdd.net/open/id/eprint/2457 |
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