Raghav, Pawan Kumar and Kumar, Rajesh and Kumar, Vinod and Raghava, Gajendra P S (2019) Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells. Molecular genetics & genomic medicine, 7 (11). e910. ISSN 2324-9269
Full text not available from this repository. (Request a copy)Abstract
Inducing apoptosis in cancer cells is an important step for the successful treatment of cancer patients. Bcl-2 is an antiapoptotic protein which determines apoptosis by interacting with proapoptotic members of the Bcl-2 family. Exome sequencing has identified Bcl-2 and Bax missense mutations in more than 40 cancer types. However, a little information is available about the functional impact of each Bcl-2 and Bax mutation on the pathogenesis of cancer.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Wiley |
| Uncontrolled Keywords: | Bax; Bcl-2; apoptosis; cancer; docking; mutation |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Mathematics |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 05 Dec 2019 14:03 |
| Last Modified: | 05 Dec 2019 14:03 |
| URI: | http://crdd.osdd.net/open/id/eprint/2488 |
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