Kumar, Sanjeet and Bansal, Kanika and Patil, Prashant P and Kaur, Amandeep and Kaur, Satinder and Jaswal, Vivek and Gautam, Vikas and Patil, Prabhu B (2020) Genomic insights into evolution of extensive drug resistance in Stenotrophomonas maltophilia complex. Genomics, 112 (6). pp. 4171-4178. ISSN 1089-8646
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We report first complete genomic investigation of extensive drug resistance (XDR) in a nosocomial Stenotrophomonas maltophilia complex strain that is resistant to mainstream drugs (trimethoprim/sulfamethoxazole and levofloxacin). Comprehensive genomic investigation revealed its exclusive fourteen dynamic regions and highly enriched resistome comprising of two sulfonamide resistance genes on two diverse super-integrons of chromosomal origin. In addition, both these integrons harbour array of antibiotic resistance and commonly used disinfectant's resistance genes linked to ISCR elements. Isolation of a novel XDR strain from Indian tertiary care unit belonging to novel ST with diverse array of resistance genes on ISCR linked super-integrons indicates extent and nature of selection pressure in hospitals. Since, repetitive elements have major role in their spread and due to limitations of draft genomes, there is an urgent need to employ complete genome-based investigation for tracking the emergence of XDR at global level and designing strategies of antimicrobial stewardship and disinfection.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to Elsevier Science. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 31 Dec 2020 05:35 |
| Last Modified: | 31 Dec 2020 05:35 |
| URI: | http://crdd.osdd.net/open/id/eprint/2629 |
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