Rajput, Akanksha and Kumar, Archit and Megha, Kirti and Thakur, Anamika and Kumar, Manoj (2021) DrugRepV: a compendium of repurposed drugs and chemicals targeting epidemic and pandemic viruses. Briefings in Bioinformatics, 22 (2). pp. 1076-1084. ISSN 1467-5463
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Viruses are responsible for causing various epidemics and pandemics with a high mortality rate e.g. ongoing SARS-CoronaVirus-2 crisis. The discovery of novel antivirals remains a challenge but drug repurposing is emerging as a potential solution to develop antivirals in a cost-effective manner. In this regard, we collated the information of repurposed drugs tested for antiviral activity from literature and presented it in the form of a user-friendly web server named 'DrugRepV'. The database contains 8485 entries (3448 unique) with biological, chemical, clinical and structural information of 23 viruses responsible to cause epidemics/pandemics. The database harbors browse and search options to explore the repurposed drug entries. The data can be explored by some important fields like drugs, viruses, drug targets, clinical trials, assays, etc. For summarizing the data, we provide overall statistics of the repurposed candidates. To make the database more informative, it is hyperlinked to various external repositories like DrugBank, PubChem, NCBI-Taxonomy, Clinicaltrials.gov, World Health Organization and many more. 'DrugRepV' database (https://bioinfo.imtech.res.in/manojk/drugrepv/) would be highly useful to the research community working to develop antivirals.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to Oxford Academic. |
| Uncontrolled Keywords: | ARS-CoV-2; drug repurposing; pandemics/epidemics; viruses; web server |
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR355 Virology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 30 Mar 2021 06:33 |
| Last Modified: | 30 Mar 2021 06:33 |
| URI: | http://crdd.osdd.net/open/id/eprint/2665 |
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