Rathore, Yogendra S and Shukla, Jinal and Mittal, BR and Singh, G and Gopal, K. and Kumar, R and Bal, Amanjit and Laroiya, I and Lakhanpal, T (2021) Radiolabelled trastuzumab Fab as a theranostic molecule for HER2 positive breast cancers. ANNALS OF ONCOLOGY, 32 (2). ISSN 0923-7534
Full text not available from this repository. (Request a copy)Abstract
nherited genes, hormonal imbalance, environmental factors, and mutation in genes are responsible for the development of breast cancer in females. Nowadays, passive immunotherapy is used to combat cancer. Trastuzumab is a humanized monoclonal antibody (mAb) and has a pronounced effect when used as adjuvant therapy, but high doses (4-8 mg/kg) and greater molecular weight (MW) increases liver retention. To fill this hiatus, antibody fragments (Fab) are generated and showed similar target specificity. The radiolabelling of Fab may provide the theranostic application in breast cancer patients.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to ELSEVIER |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 28 May 2021 05:02 |
| Last Modified: | 26 Jul 2022 06:38 |
| URI: | http://crdd.osdd.net/open/id/eprint/2681 |
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