Chaudhary, Surbhi and Patidar, Anil and Dhiman, Asmita and Chaubey, Gaurav Kumar and Dilawari, Rahul and Talukdar, Sharmila and Modanwal, Radheshyam and Raje, Manoj (2021) Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells. CELL DEATH & DISEASE, 12 (10).

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Abstract

Rapid clearance of apoptotic cells by phagocytes is crucial for organogenesis, tissue homeostasis, and resolution of inflammation. This process is initiated by surface exposure of various ‘eat me’ ligands. Though phosphatidylserine (PS) is the best recognized general recognition ligand till date, recent studies have shown that PS by itself is not sufficient for clearance of apoptotic cells. In this study, we have identified a specific pleioform of GAPDH (Glyceraldehyde 3-phosphate dehydrogenase) that functions as an ‘eat me’ signal on apoptotic cell surface. This specific form of GAPDH which is exposed on surface of apoptotic cells was found to interact with CD14 present on plasma membrane of phagocytes leading to their engulfment. This is the first study demonstrating the novel interaction between multifunctional GAPDH and the phagocytic receptor CD14 resulting in apoptotic cell clearance (efferocytosis).

Item Type:	Article
Additional Information:	Open Access
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	25 Mar 2022 04:24
Last Modified:	25 Mar 2022 04:24
URI:	http://crdd.osdd.net/open/id/eprint/2707

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