Kumar, Vinod and Patiyal, Sumeet and Kumar, Rajesh and Sahai, Sukriti and Kaur, Dilraj and Lathwal, Anjali and Raghava, Gajendra P. S. (2021) B3Pdb: an archive of blood-brain barrier-penetrating peptides. BRAIN STRUCTURE & FUNCTION, 226 (8). pp. 2489-2495.
Full text not available from this repository. (Request a copy)Abstract
The blood-brain barrier poses major hurdles in the treatment of brain-related ailments. Over the past decade, interest in peptides-based therapeutics has thrived a lot because of their higher benefit to risk ratio. However, a complete knowledgebase providing a well-annotated picture of the peptide as a therapeutic molecule to cure brain-related ailments is lacking. We have built up a knowledgebase B3Pdb on blood-brain barrier (BBB)-penetrating peptides in the present study. The B3Pdb holds clinically relevant experimental information on 1225 BBB-penetrating peptides, including mode of delivery, animal model, in vitro/in vivo experiments, chemical modifications, length. Hoping that drug delivery systems can improve central nervous system disorder-related therapeutics. In this regard, B3Pdb is an important resource to support the rational design of therapeutics peptides for CNS-related disorders. The complete ready-to-use and updated database with a user-friendly web interface is available to the scientific community at https://webs.iiitd.edu.in/raghava/b3pdb/ .
| Item Type: | Article |
|---|---|
| Additional Information: | The Copyright of this article belongs to SPRINGER |
| Uncontrolled Keywords: | Blood–brain barrier; Blood–brain barrier-penetrating peptides; Database; Drug delivery; Neurological disorders. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 29 Mar 2022 04:26 |
| Last Modified: | 29 Mar 2022 04:26 |
| URI: | http://crdd.osdd.net/open/id/eprint/2764 |
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