Microbial metabolism as an evolutionary response: the cybernetic approach to modeling.

Patnaik, P R (2001) Microbial metabolism as an evolutionary response: the cybernetic approach to modeling. Critical reviews in biotechnology, 21 (3). pp. 155-75. ISSN 0738-8551

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Abstract

The growth and metabolic capabilities of microorganisms depend on their interactions with the culture medium. Many media contain two or more key substrates, and an organism may have different preferences for the components. Microorganisms adjust their preferences according to the prevailing conditions so as to favor their own survival. Cybernetic modeling describes this evolutionary strategy by defining a goal that an organism tries to attain optimally at all times. The goal is often, but not always, maximization of growth, and it may require the cells to manipulate their metabolic processes in response to changing environmental conditions. The cybernetic approach overcomes some of the limitations of metabolic control analysis (MCA), but it does not substitute MCA. Here we review the development of the cybernetic modeling of microbial metabolism, how it may be combined with MCA, and what improvements are needed to make it a viable technique for industrial fermentation processes.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Informa Healthcare.
Uncontrolled Keywords:	microbial metabolism, response to environment, cybernetic models.
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	05 Jan 2012 15:16
Last Modified:	05 Jan 2012 15:16
URI:	http://crdd.osdd.net/open/id/eprint/284

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