Epigenetic interaction of microbes with their mammalian hosts

Rajeev, Ramisetti and Dwivedi, Ambey Prasad and Sinha, Anunay and Agarwaal, Viplove and Dev, Rachana Roshan and Kar, Anjana and Khosla, Sanjeev (2021) Epigenetic interaction of microbes with their mammalian hosts. Journal of Biosciences, 46 (4).

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Abstract

The interaction of microbiota with its host has the ability to alter the cellular functions of both, through several mechanisms. Recent work, from many laboratories including our own, has shown that epigenetic mechanisms play an important role in the alteration of these cellular functions. Epigenetics broadly refers to change in the phenotype without a corresponding change in the DNA sequence. This change is usually brought by epigenetic modifications of the DNA itself, the histone proteins associated with the DNA in the chromatin, non-coding RNA or the modifications of the transcribed RNA. These modifications, also known as epigenetic code, do not change the DNA sequence but alter the expression level of specific genes. Microorganisms seem to have learned how to modify the host epigenetic code and modulate the host transcriptome in their favour. In this review, we explore the literature that describes the epigenetic interaction of bacteria, fungi and viruses, with their mammalian hosts.

Item Type:	Article
Additional Information:	The copyright of this article belongs to Springer.
Uncontrolled Keywords:	Bacteria;DNA methylation;epigenetic modification;fungi;histone modifications;microbiota;ncRNA;viruses
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	09 Nov 2021 05:42
Last Modified:	09 Nov 2021 05:42
URI:	http://crdd.osdd.net/open/id/eprint/2922

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