Mohammad, Aqdas and Maurya, Sudeep K and Pahari, Susanta and Singh, Sanpreet and Khan, Nargis and Sethi, Kanupriya and Kaur, Gurpreet and Agrewala, J N (2021) Immunotherapeutic Role of NOD-2 and TLR-4 Signaling as an Adjunct to Antituberculosis Chemotherapy. ACS applied materials & interfaces. pp. 2999-3008. ISSN 1944-8252
Full text not available from this repository. (Request a copy)Abstract
Tuberculosis (TB) treatment is lengthy and inflicted with severe side-effects. Here, we attempted a novel strategy to reinforce host immunity through NOD-like receptor (NOD-2) and Toll-like receptor (TLR-4) signaling in the murine model of TB. Intriguingly, we noticed that it not only bolstered the immunity but also reduced the dose and duration of rifampicin and isoniazid therapy. Further, we observed expansion in the pool of effector (CD44hi, CD62Llo, CD127hi) and central (CD44hi, CD62Lhi, CD127hi) memory CD4 T cells and CD8 T cells and increased the intracellular killing of Mycobacterium tuberculosis (Mtb) by activated dendritic cells [CD86hi, CD40hi, IL-6hi, IL-12hi, TNF-αhi, nitric oxide (NO)hi] with significant reduction in Mtb load in the lungs and spleen of infected animals. We infer that the signaling through NOD-2 and TLR-4 may be an important approach to reduce the dose and duration of the drugs to treat TB.
| Item Type: | Article |
|---|---|
| Additional Information: | The Copyright of this article belongs to ACS |
| Uncontrolled Keywords: | Mycobacterium tuberculosis; antibiotics; host-directed therapy. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 18 Apr 2022 04:11 |
| Last Modified: | 18 Apr 2022 04:11 |
| URI: | http://crdd.osdd.net/open/id/eprint/2944 |
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