Singh, Mona and Thakur, Mony and Mishra, Manish and Vibhuti, Rajkamal and Menon, A.M and Nagda, Girima and Dwivedi, V and Dakal, T.C and Yadav, Vinod (2021) Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions. Immunology letters, 240. pp. 123-136. ISSN 0165-2478
Full text not available from this repository. (Request a copy)Abstract
Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied inducible cell adhesion molecules which is responsible for several immune functions like T cell activation, extravasation, inflammation, etc. The molecule is constitutively expressed over the cell surface and is regulated up / down in response to inflammatory mediators like cellular stress, proinflammatory cytokines, viral infection. These stimuli modulate the expression of ICAM-1 primarily through regulating the ICAM-1 gene transcription. On account of the presence of various binding sites for NF-κB, AP-1, SP-1, and many other transcription factors, the architecture of the ICAM-1 promoter become complex. Transcription factors in union with other transcription factors, coactivators, and suppressors promote their assembly in a stereospecific manner on ICAM-1 promoter which mediates ICAM-1 regulation in response to different stimuli. Along with transcriptional regulation, epigenetic modifications also play a pivotal role in controlling ICAM-1 expression on different cell types. In this review, we summarize the regulation of ICAM-1 expression both at the transcriptional as well as post-transcriptional level with an emphasis on transcription factors and signaling pathways involved.
| Item Type: | Article |
|---|---|
| Additional Information: | The Copyright of this article belongs to ELSEVIER |
| Uncontrolled Keywords: | Chromatin modification; Cytokines; ICAM-1; Inflammation |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Law, Arts and Social Sciences > School of Law Faculty of Law, Arts and Social Sciences > School of Management Faculty of Law, Arts and Social Sciences > School of Social Sciences Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 19 Apr 2022 04:50 |
| Last Modified: | 19 Apr 2022 04:50 |
| URI: | http://crdd.osdd.net/open/id/eprint/2958 |
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