Gupta, Aikan and Sharma, Yogesh and Pawar, Ganesh P. and Ashish , Ashish and Nihalani, D and Chaudhari, Vinod (2022) An efficient and scalable synthesis of Isodesmosine. Journal of Heterocyclic Chemistry, 59 (5). pp. 958-963.
Full text not available from this repository. (Request a copy)Abstract
Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to Wiley |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 22 Jul 2022 04:27 |
| Last Modified: | 22 Jul 2022 04:27 |
| URI: | http://crdd.osdd.net/open/id/eprint/2977 |
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