Patel, Naisargee and Zinzuvadia, Aarushi and Prajapat, Mitali and Tyagi, Rajeev K and Dalai, Sarat (2022) Swertiamarin-mediated immune modulation/adaptation confers protection against Plasmodium berghei. Future Microbiology .
Full text not available from this repository. (Request a copy)Abstract
Aims: Development of resistance by the malaria parasite, a systemic inflammatory and infectious pathogen, has raised the need for novel efficacious antimalarials. Plant-derived natural compounds are known to modulate the immune response and eradicate the infectious pathogens. Therefore we carried out experiments with swertiamarin to dissect its anti-inflammatory and immunomodulatory potential. Materials & methods: We carried out studies in Swiss albino mice that received infectious challenge with Plasmodium berghei and swertiamarin treatment in a prophylactic manner. Results & conclusion: Oral administration of swertiamarin prior to infectious challenge with P. berghei in experimental mice showed delayed parasite development as compared with untreated control. IFN-γ and IL-10 appeared to be adapted/modulated by regular swertiamarin treatment. Further, withdrawal of swertiamarin pressure did not affect parasite replication. However, the short half-life of swertiamarin limited its long-lasting therapeutic effect, requiring higher and frequent dosing schedules.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to Future Medicine |
| Uncontrolled Keywords: | Plasmodium; adaptation; combination therapy; cytokines; immunomodulatory; inflammation; swertiamarin |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 25 Jul 2022 05:33 |
| Last Modified: | 25 Jul 2022 05:33 |
| URI: | http://crdd.osdd.net/open/id/eprint/2988 |
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