Molecular Epidemiology and Polymorphism Analysis in Drug-Resistant Genes in M. tuberculosis Clinical Isolates from Western and Northern India

Rana, Vibhuti and Singh, Nittu and Nikam, Chaitali and Kambli, Priti and Singh, Pravin Kumar and Singh, Urmila and Jain, Amita and Rodrigues, Camilla and Sharma, Charu (2022) Molecular Epidemiology and Polymorphism Analysis in Drug-Resistant Genes in M. tuberculosis Clinical Isolates from Western and Northern India. Infection and Drug Resistance , 15. pp. 1717-1732.

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Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC90052...

Abstract

The mechanistic details of first line drug (FLD) resistance have been thoroughly explored but the genetic resistance mechanisms of second line injectables, which form the backbone of the combinatorial drug resistant tuberculosis therapy, are partially identified. This study aims to highlight the genetic and spoligotypic differences in the second line drug (SLD) resistant and sensitive Mycobacterium tuberculosis (Mtb) clinical isolates from Mumbai (Western India) and Lucknow (Northern India).

Item Type: Article
Additional Information: The copyright of this article belongs to Dove Press
Uncontrolled Keywords: drug resistant tuberculosis; single nucleotide polymorphism; rrs; eis; whiB7; spoligotyping
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 25 Jul 2022 05:46
Last Modified: 25 Jul 2022 05:46
URI: http://crdd.osdd.net/open/id/eprint/2990

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