Kumar, Reetesh and Srivastava, Yogesh and Muthuramalingam, Pandiyan and Singh, Kumar Sunil and Verma, Geetika and Tiwari, Savitri and Tandel, Nikunj and Beura, Kumar Samir and Panigrahi, Ramachandra Abhishek and Maji, Somnath and Sharma, Prakriti and Rai, Kumar Pankaj and Prajapati , Kumar Dinesh and Shin , Hyunsuk and Tyagi, Rajeev K (2023) Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis. Viruses Basel , 15 (4).
Full text not available from this repository. (Request a copy)Abstract
Genetic variant(s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses of spike protein mutations in the significant variant clade of SARS-CoV-2, using the data available on the Nextstrain server. We selected various mutations, namely, A222V, N439K, N501Y, L452R, Y453F, E484K, K417N, T478K, L981F, L212I, N856K, T547K, G496S, and Y369C for this study. These mutations were chosen based on their global entropic score, emergence, spread, transmission, and their location in the spike receptor binding domain (RBD). The relative abundance of these mutations was mapped with global mutation D614G as a reference. Our analyses suggest the rapid emergence of newer global mutations alongside D614G, as reported during the recent waves of COVID-19 in various parts of the world. These mutations could be instrumentally imperative for the transmission, infectivity, virulence, and host immune system's evasion of SARS-CoV-2. The probable impact of these mutations on vaccine effectiveness, antigenic diversity, antibody interactions, protein stability, RBD flexibility, and accessibility to human cell receptor ACE2 was studied in silico. Overall, the present study can help researchers to design the next generation of vaccines and biotherapeutics to combat COVID-19 infection.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to MDPI |
| Uncontrolled Keywords: | COVID-19; SARS-CoV-2; VoC; evolution; mutations; spike protein. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 07 Jun 2023 11:20 |
| Last Modified: | 07 Jun 2023 11:20 |
| URI: | http://crdd.osdd.net/open/id/eprint/3091 |
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