Rajeev, Ramisetti and Mishra, Rakesh K. and Khosla, Sanjeev (2024) DNMT3L interacts with Piwi and modulates the expression of piRNAs in transgenic Drosophila. EPIGENOMICS, 16 (6). pp. 375-388.
Full text not available from this repository. (Request a copy)Abstract
Aim: To explore the role of Piwi protein and piRNAs in DNMT3L-mediated epigenetic inheritance. Materials & methods: Transgenic Drosophila were used to examine the effect of ectopically expressed DNMT3L on the profile of piRNAs by sequencing of small RNAs. Results & conclusion: Our previous work showed accumulation and inheritance of epimutations across multiple generations in transgenic DNMT3L Drosophila. Here, we show interaction of DNMT3L with Piwi and a significant alteration in the piRNA profile across multiple generations in transgenic Drosophila. In the light of its interaction with histone H1, we propose that in addition to its role of modulating core histone modifications, DNMT3L allows for inheritance of epigenetic information through its collaboration with Piwi, piRNAs and histone H1.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to TAYLOR AND FRANCIS |
| Uncontrolled Keywords: | DNMT3L; Drosophila; Piwi; chromatin; epigenetic inheritance; histone H1; piRNA. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 25 Jun 2024 02:01 |
| Last Modified: | 25 Jun 2024 02:01 |
| URI: | http://crdd.osdd.net/open/id/eprint/3134 |
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