Negi, Sushmita and Tandel, Nikunj and Garg, Neeraj K. and Sharma, Prakriti and Kumar, Rajinder and Sharma, Praveen and Kumar, Reetesh and Saini, Sheetal and Sharma, Aman and Tyagi, Rajeev K. (2024) Co-Delivery of Aceclofenac and Methotrexate Nanoparticles Presents an Effective Treatment for Rheumatoid Arthritis. INTERNATIONAL JOURNAL OF NANOMEDICINE, 19. pp. 2149-2177.
Full text not available from this repository. (Request a copy)Abstract
Background: Rheumatoid arthritis (RA) is a common acute inflammatory autoimmune connective tissue arthropathy. The genetic studies, tissue analyses, experimental animal models, and clinical investigations have confirmed that stromal tissue damage and pathology driven by RA mounts the chronic inflammation and dysregulated immune events. Methods: We developed methotrexate (MTX)-loaded lipid-polymer hybrid nanoparticles (MTX-LPHNPs) and aceclofenac (ACE)-loaded nanostructured lipid carriers (ACE-NLCs) for the efficient co-delivery of MTX and ACE via intravenous and transdermal routes, respectively. Bio-assays were performed using ex-vivo skin permeation and transport, macrophage model of inflammation (MMI) (LPS-stimulated THP-1 macrophages), Wistar rats with experimental RA (induction of arthritis with Complete Freund's adjuvant; CFA and BCG), and programmed death of RA affected cells. In addition, gene transcription profiling and serum estimation of inflammatory, signaling, and cell death markers were performed on the blood samples collected from patients with RA.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to DOVE PRESS |
| Uncontrolled Keywords: | MMP-1; aceclofenac; lipid polymer hybrid nanoparticles; methotrexate; nanostructured lipid nanocarriers; rheumatoid arthritis. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 25 Jun 2024 04:04 |
| Last Modified: | 25 Jun 2024 04:04 |
| URI: | http://crdd.osdd.net/open/id/eprint/3140 |
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