Pirhaghi, Mitra and Mamashli, Fatemeh and Moosavi-Movahedi, Faezeh and Arghavani, Payam and Amiri, Ahmad and Davaeil, Bagher and Mohammad-Zaheri, Mahya and Mousavi-Jarrahi, Zahra and Sharma, Deepak and Langel, Ulo and Otzen, Daniel Erik and Saboury, Ali Akbar (2024) Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases. MOLECULAR PHARMACEUTICS, 21 (5). pp. 2097-2117.
Full text not available from this repository. (Request a copy)Abstract
Currently, one of the most significant and rapidly growing unmet medical challenges is the treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). This challenge encompasses the imperative development of efficacious therapeutic agents and overcoming the intricacies of the blood-brain barrier for successful drug delivery. Here we focus on the delivery aspect with particular emphasis on cell-penetrating peptides (CPPs), widely used in basic and translational research as they enhance drug delivery to challenging targets such as tissue and cellular compartments and thus increase therapeutic efficacy. The combination of CPPs with nanomaterials such as nanoparticles (NPs) improves the performance, accuracy, and stability of drug delivery and enables higher drug loads. Our review presents and discusses research that utilizes CPPs, either alone or in conjugation with NPs, to mitigate the pathogenic effects of neurodegenerative diseases with particular reference to AD and PD.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to ACS |
| Uncontrolled Keywords: | Alzheimer’s disease (AD); Parkinson’s disease (PD); cell-penetrating peptides; central nervous system disorders; drug delivery; peptide-nanoparticle conjugate. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 25 Jun 2024 04:05 |
| Last Modified: | 25 Jun 2024 04:05 |
| URI: | http://crdd.osdd.net/open/id/eprint/3141 |
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