Chaubey, Gaurav Kumar and Dilawari, Rahul and Modanwal, Radheshyam and Talukdar, Sharmila and Dhiman, Asmita and Raje, Chaaya Iyengar and Raje, Manoj (2023) Excess iron aggravates the severity of COVID-19 infection. Free radical biology & medicine, 208. pp. 186-193. ISSN 1873-4596
Full text not available from this repository. (Request a copy)Abstract
Coronavirus disease-19 (COVID-19) can induce severe inflammation of the lungs and respiratory system. Severe COVID-19 is frequently associated with hyper inflammation and hyper-ferritinemia. High iron levels are known to trigger pro-inflammatory effects. Cumulative iron loading negatively impacts on a patients innate immune effector functions and increases the risk for infection related complications. Prognosis of severe acute respiratory SARS-CoV-2 patients may be impacted by iron excess. Iron is an essential co-factor for numerous essential cellular enzymes and vital cellular operations. Viruses hijack cells in order to replicate, and efficient replication requires an iron-replete host. Utilizing iron loaded cells in culture we evaluated their susceptibility to infection by pseudovirus expressing the SARS-CoV-2 spike protein and resultant cellular inflammatory response. We observed that, high levels of iron enhanced host cell ACE2 receptor expression contributing to higher infectivity of pseudovirus. In vitro Cellular iron overload also synergistically enhanced the levels of; reactive oxygen species, reactive nitrogen species, pro-inflammatory cytokines (IL-1β, IL-6, IL-8 & TNF-α) and chemokine (CXCL-1&CCL-4) production in response to inflammatory stimulation of cells with spike protein. These results were confirmed using an in vivo mouse model. In future, limiting iron levels may be a promising adjuvant strategy in treating viral infection.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to Elsevier Science |
| Uncontrolled Keywords: | COVID-19; Iron; Pro-inflammatory cytokines; Reactive nitrogen species; Reactive oxygen species; SARS-CoV-2. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 16 Jul 2024 02:57 |
| Last Modified: | 16 Jul 2024 02:57 |
| URI: | http://crdd.osdd.net/open/id/eprint/3169 |
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